Sri Sakthi Amma Institute of Biomedical Research (SSAIBR) (previously The Division of Biomedical Research) was established in July 2008 and opened by Dr. Lalit Kant, Sr. Deputy Director General, Indian Council of Medical Research (ICMR). Sri Narayani Hospital and Research Centre (SNH&RC) is a Department of Scientific and Industrial Research (DSIR) (Government of India) recognized institution for Biomedical Research since 2009. The division is dedicated to quality research on various aspects of molecular biology, virology, bioinformatics, public health, ayurveda, cancer, endocrine and cardiovascular diseases. The SNH&RC provides top quality support to the departments community research, creative activity, and outreach/policy initiatives.
Our mission is to be recognized nationally and internationally as a leader in the quest for excellence in basic and applied biomedical research. Our vision is to discover, develop, publish, and apply knowledge of basic and clinical biomedical research to improve human health through world-class medical research towards the mandated mission.
As part of our mandate, we:
- Encourage and support research to improve human health through external grants and in-house funds.
- Handle resource databases and serve as a focal point for training biomedical researchers including basic and clinical researchers through interactions and teamwork.
- Provide a platform for deserving academics (M.Sc./MBBS/Ph.D.) to pursue research in the biomedical field.
- The emphasis is on promoting research on the health problems of tribal, rural and peri-urban populations.
- Actively interact and build bridges with the community to promote wellbeing of the community.
- Advance and disseminate knowledge and technology to improve the quality of life and economic competitiveness of our people.
|Dr. Balaji Nandagopal, Ph.D., MACE., FIMSA., FACSc, MBA
Professor & Director, SSAIBR & SNH&RC
Research interests: Molecular diagnosis and epidemiology of Infectious diseases and non-infectious diseases
|Dr. R. Mageshbabu Ph.D., MIMSA
Associate Professor / Senior Scientist and Head
Research interests: Molecular diagnosis and epidemiology of viral diseases
|Dr. Sathish Sankar Ph.D., MIMSA
Associate Professor / Senior Scientist
Research interests: Molecular epidemiology of viral and bacterial infections
|Dr. Devamani Pandian M.S. (Ob/Gyn), M.Med.Sci (ART)
Research interests: TORCH-S infections in pregnant women
|Dr. Kavitha Balaji MBBS, DGO
Research interests: Metabolic syndromes in pregnant women
|Mr. V. Kumaran M.Sc.
Research interests: Molecular diagnosis of Parvovirus B19
|Mr. S. Kalaiselvan M.Sc.
Research interests: Molecular diagnosis of Hantavirus
|Ms. S. Suganya M.Sc., M.Phil.,
Research interests: Ayurvedic Biology
Former Ph.D. Students
|Dr. Ebi Ashley George under the guidance of Dr. N. Balaji
PhD topic: Isolation and molecular characterization of Extended spectrum beta lactamase producing E. coli from humans and environment
|Dr. N. Harikrishnan under the guidance of Dr. S. Sathish
PhD topic: Molecular detection and characterization of human metapneumovirus and human bocavirus and the clonal relatedness of the strains circulating among children in a rural setting of Vellore district, Tamil Nadu
|Dr. Gopalan Sridharan Ph.D. FRCPath
Advisor and Emeritus Scientist
|Dr. KA Balasubramanian Ph.D., FAMS, FASc,
Advisor and Emeritus Scientist
|Dr. Mary V Jesudason DCP., MD, FAMS
Advisor and Emeritus Scientist
|Dr. L. Mahadevan BAMS., MD
Governing Body for Research
|Chairman: Dr. UC Chaturvedi|
|Dr. N. Balaji (Member Secretary)|
|Dr. Deepak Gadkari (External expert)|
|Prof. SP. Thyagarajan (External expert)|
|Dr. Baby Padmini (External expert)|
|Dr. G. Sridharan|
Scientific Advisory Committee
|Chairman: Dr. KA Balasubramanian|
|Dr. N. Balaji|
|Dr. G. Sridharan|
|Dr. Padma Srikanth|
Institutional Review Board of SSAIBR, unit of SNH & RC
|Spiritual Head: Sri Sakthi Amma (Swamijee)|
|Chairman: Dr. Baby Padmini
(HOD, Microbiology, GKNM Hospital, Coimbatore. T.N)
|Dr. N. Balaji (Director, SSAIBR and SNH&RC)
|Dr. KA Balasubramanian (Biomedical Scientist,
|Dr. G. Sridharan (Biomedical Scientist,
Advisor, SSAIBR, SNH&RC)
|Mr. J. Chitti Babu (Legal Expert, Vellore)|
|Mr. M. Kalaiarasan MLA (Annaikut), Vellore Dist. (Prominent Citizen)|
|Dr. TVS. Dattatreya Murthy (Physician, SNH&RC)|
|Dr. Aravindan Nair (Medical Superintendent, SNH&RC)|
Dedicated molecular biology facility as an independent unit with complete access for researchers to microbiology, hematology and biochemistry facilities of the department of laboratory medicine of SNH&RC
National level CME / Conference organized
1. CME programme on Recent Advances in Infectious Diseases with distinguished ICMR scientists from different ICMR institutes on July 2008.
2. CME programme at SNHRC under the auspices of International Association of Medical and Pharmaceutical Virologists on Oct 2 2010. Title: “New Frontiers in Human Viral Diseases”. This programme was well attended and utilized by graduates and post-graduates from various academic and research institutions.
3. Symposium on Viral infections of Public Health Importance on 3rd November 2012 under the sponsorship of ICMR and SNH&RC.
4. SNHRC and IMSA Joint CME on “Recent trends in the understanding of emerging infectious diseases of India” on 7th December 2013
List of publications (in peer-reviewed national and international journals)
1. Balaji Nandagopal, Kavitha Balaji, Karthikeyan L, and Rekha N, Syphilis is predominantly an urban problem in Vellore district of Tamilnadu, Indian Journal of Sexually Transmitted Disease 2008; 29(1): 46-47
2. Balaji N, Nadarajah R, Sathish Sankar, Varadhan C, Hepatitis B Virus and Human immunodeficiency virus infections are a public health problem even in rural communities of Vellore district, Tamil Nadu, Indian Journal of Medical Microbiology 2009; 27(1): 80-81
3. Nandagopal B, Sankar S, Karthikeyan L, Appu KC, Padmini B, Sridharan G, Gopinath AK. Prevalence of Salmonella typhi among patients with febrile illness in rural and peri-urban population of Vellore district as determined by a nested PCR targeting the flagellin gene. Molecular Diagnosis and Therapy 2010; 14(2):107-12
4. Nandagopal B, Sankar S, Lingesan K, Appu KC, Sridharan G, Gopinathan AK. Evaluation of a nested PCR targeting IS6110 of Mycobacterium tuberculosis for detection of the organism in the leukocyte fraction of blood samples. Indian Journal of Medical Microbiology 2010; 28(3): 227-32
5. Balaji K, Sankar S, Balaji Nandagopal. Low birth weight of newborns: magnitude of the problem seen in a 100 bed hospital of a rural area in Vellore District, Tamilnadu (India). Indian Journal of Community Medicine 2010; 35(2): 361-3
6. Kannangai R, Abraham AM, Sankar S, Sridharan G. Nanotechnology tools for single-virus particle detection (Review). Indian Journal of Medical Microbiology 2010; 28(10): 95-9
7. Sankar S, Balakrishnan B, Nandagopal B, Thangaraju T, Natarajan S. Comparative evaluation of a nested PCR and conventional smear technique for the detection of Mycobacterium tuberculosis in sputum samples. Molecular Diagnosis and Therapy 2010; 14(4): 223-7
8. Sankar S, Balakrishnan B, Nandagopal B, Thangaraju T, Natarajan S. Comparative evaluation of two PCRs targeting different genomic region to detect Mycobacterium tuberculosis in sputum. Indian Journal of Medical Microbiology 2010; 28(4): 331-5
9. Sankar S, Ramamurthy M, Nandagopal B, Sridharan G. An appraisal of the polymerase chain reaction based technology in the detection of Mycobacterium tuberculosis. Molecular Diagnosis and Therapy 2011; 14(6): 1-11
10. Nandagopal B, Sankar S, Ramamurthy M, Sathish S, Sridharan G. Could the products of Indian medicinal plants be the next alternative for the treatment of infections? Indian Journal of Mdical Microbiology 2011; 29(2): 93-101
11. Sankar S, Kuppanan S, Balakrishnan B, Nandagopal B. In-silico analysis of sequence diversity among IS6110 sequence of Mycobacterium tuberculosis: possible implications for PCR based detection. Bioinformation 2011; 6(11): 1-3
12. Sankar S, Ramamurthy M, Nandagopal B, Srikanth P, Venkatraman G, Sridharan G. Molecular and nanotechnological approach to etiological diagnosis of infectious syndromes. Molecular Diagnosis and Therapy 2011; 15(3): 145-158
13. Nandagopal B, Sankar S, Lingesan K, Appu KC, Sridharan G, Gopinathan AK. Application of PCR to detect Burkholderia pseudomallei and Brucella species in buffy coat from patients with febrile illness among rural and peri-urban population. Journal of Global Infectious Diseases 2012; 4(1):34-40
14. Sankar S, Narayanan H, Kuppanan S, Nandagopal B. Frequency of ESBL-producing Gram negative bacilli in a 200 bed multi-specialty hospital in Vellore district, Tamil Nadu, India – a prospective, cross-sectional study. Infection 2012; 40(4): 425-429
15. Narayanan H, Sankar S, Simoes EAF, Nandagopal B, Sridharan G. Molecular detection of human metapneumovirus and human bocavirus on oropharyngeal swabs collected from young children with acute respiratory tract infection from rural and peri-urban communities of India (South). Molecular Diagnosis and Therapy 2013 17(2): 107-115
16. Narayanan H, Sankar S, Simoes EAF, Nandagopal B, Sridharan G. Analysis of sequence diversity of Human metapneumovirus collected from young children with acute respiratory tract infections in India (South). Molecular Diagnosis and Therapy 2013 Aug;17(4):247-55.
17. Sankar S, Kuppanan S, Nandagopal B, Sridharan G. Diversity of Salmonella enterica serovar Typhi strains collected from India using variable number tandem repeats-PCR analysis. Molecular Diagnosis and Therapy 2013 Aug;17(4):257-64.
18. Ramamurthy M, Srikanth P, Seshan V, Sarangan G, Sankar S, Nandagopal B, Sridharan G. Arboviruses of Importance In India: Part I. Biological, transmission characteristics, certain unique issues and clinical features. Sri Ramachandra Journal of Medicine 2013 6(1): 22-30
19. Ramamurthy M, Srikanth P, Seshan V, Sarangan G, Sankar S, Nandagopal B, Sridharan G. Arboviruses of importance in India: Part II. Epidemiology, Laboratory Diagnosis, Treatment, Prevention and Control. Sri Ramachandra Journal of Medicine 2013 Jul – Dec 2013; 6(2): 6-16
20. George EA, Sankar S, Jesudason MV, Sudandiradoss C, Nandagopal B. Incidence of extended spectrum β-lactamase producing Escherichia coli among patients, healthy individuals and environment. Indian Journal of Medical Microbiology 2014 32(2): 172-174
21. Sankar S, Vadivel K, Nandagopal B, Jesudason MV, Sridharan G. A multiplex nested PCR for the simultaneous detection of Salmonella typhi, Mycobacterium tuberculosis and Burkholderia pseudomallei in patients with pyrexia of unknown origin (PUO) in Vellore, South India. Molecular Diagnosis and Therapy 2014 18(3): 315-321
22. George EA, Sankar S, Jesudason MV, Sudandiradoss C, Nandagopal B. Molecular characterization of CTX-M type extended spectrum β-lactamase (ESBL) producing E. coli isolated from humans and the environment”. Indian J Med Microbiol 2015 33(5): 73-79
23. Nandagopal B, Sankar S, Sagadevan K, Arumugam H, Jesudason MV, Aswathaman K, Nair A. Frequency of extended spectrum β-lactamase producing urinary isolates of Gram negative bacilli among patients seen in a multispecialty hospital in Vellore district, India. Indian J Med Microbiol 2015; 33(2): 282-5
24. Sankar S, Upadhyay M, Ramamurthy M, Vadivel K, Sagadevan K, Nandagopal B, Vivekanandan P, Sridharan G. Novel insights on hantavirus evolution: the dichotomy in evolutionary pressures acting on different hantavirus segments. PLoS One 2015 10(7): e0133407
Textbook / Textbook Chapters
1. Kannangai R and Sridharan G. In: Dehydroepiandrosterone in Human Immunodeficiency Virus infection monitoring and therapy. Editor:Watson RR. CRC Press, FL, USA 2011.
2. Sankar S, Nandagopal B, Ramamurthy M and Sridharan G. Nano Optical Sensors in Virology. In: Optochemical Nano Sensors. Editors: Arregui FJ, Cusano A, Cutolo A, Giordano M. CRC Press, FL, USA 2012.
3. Ramamurthy M, Rajesh Kannangai, Asha Mary Abraham and Gopalan Sridharan. Viral Infections in immunocompromised hosts (Virology textbook of National Academy of Sciences of India). (In press)
4. Asha Mary Abraham, G.V. Asokan, Balaji Nandagopal, G. John Fletcher, R. Magesh Babu, Priya Abraham, Sathish Sankar, Shoba Mammen, G. Sridharan. Reviews in Medical and Veterinary Virology, to be published by Scientific Publishers, India for the post-graduate textbook series 21st Century Biology and Agriculture. (In-Press)
Applications are invited for one post of Junior Project Research Fellow at Sri Sakthi Amma Institute of Biomedical Research to work under a ICMR sponsored project.
Note: Only Men needs to apply because of night sample collection and field work.
1. ICMR project: Molecular detection and characterization of human metapneumovirus and human bocavirus in a rural and peri-urban community of Vellore district in Tamil Nadu.
2. ICMR Project: Development and evaluation of multiplex PCR for the simultaneous detection of Salmonella typhi, Mycobacterium tuberculosis and Burkholderia pseudomallei for application on clinical samples
3. CSIR Project: Molecular epidemiology of Indian strains of Salmonella enterica serovar Typhi: a phylogenetic approach by examining the molecular diversity of variable number tandem repeats (VNTR)
4. ICMR Project: A search for Parvovirus B19 disease using a polymerase chain reaction assay for viral DNA and IgM determination in certain high-risk clinical conditions among rural and peri-urban population of Vellore District in Tamil Nadu
5. ICMR Project: Molecular detection and genotypic characterization of hanta virus in acute febrile illness among rural and peri-urban population of Vellore district, Tamil Nadu by using the Real time reverse transcription PCR assay and nucleotide sequencing.